Page 60 - Livre électronique des RFTP 2024

P10. 15-EPI-LIPOXIN A4: A KEY MEDIATOR IN CHRONIC

OBSTRUCTIVE PULMONARY DISEASE

JELASSI.W, HEDHLI.A, EUCHI.K, KHALFALLAH.N, MJID.M, CHEIKHROUHOU.S,
OUAHCHI.Y, TOUJANI.S, DHAHRI.B

PULMONOLOGY DEPARTMENT, LR18SP02, LA RABTA HOSPITAL, TUNIS EL MANAR UNIVERSITY,
TUNIS, TUNISIA

INTRODUCTION :

Chronic Obstructive Pulmonary Disease (COPD) is marked by ongoing systemic
inflammation. Recognizing this connection is vital for managing the disease
effectively. One key mediator in inflammation resolution is 15-epi-lipoxin A4, a
specialized lipid derived from arachidonic acid metabolism. It plays a critical role in
damping inflammation and fostering tissue repair processes.

Our study aimed to evaluate the levels of 15-Epi-LXA4 in patients with COPD
compared to controls, and to analyze this mediator according to disease severity.

METHODS:

We conducted a prospective case-control study at the Pulmonology-Allergology
department of La Rabta Hospital between March and September 2022, including
40 male patients with confirmed stable COPD. This group was matched with the
control group. Patients with concomitant respiratory disease associated with COPD
and/or receiving immunosuppressive treatment were excluded. Patients were
interviewed and examined. Disease severity was assessed using the ABCD tool of
the Global Initiative on Obstructive Lung Disease 2022 (GOLD). Blood samples for
15-Epi-Lipoxin A4 (15-Epi-LXA4) and Arachidonic acid (AA) measurement, as well
as spirometry, were performed.

RESULTS:

In the patient group, the average age was 64 ±8 years, compared to 59±7 years in
the control group. COPD was categorized as stage 3 in 17% of cases and stage 4 in
17% of cases. According to the ABCD assessment tool, patients were distributed as
follows: GOLD A in 5%, GOLD B in 55%, GOLD C in 20%, and GOLD D in 20%. No
significant difference was found in 15-Epi-LXA4 and AA levels between the two
groups. The cut-off value to predict the risk of COPD was 0.48 pg/ml for 15-Epi-
LXA4 with an Odds ratio of 2,538 [(1,023 - 6,298), P<10-3]. This mediator was
negatively correlated with the age of smoking onset (r= -0,437; P<10-3). A negative
correlation was also found between chronic respiratory impairment and 15EpiLXA4
(r=-0,616; p=0,002). However, no correlation was found between AA levels and
COPD severity.

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