Page 57 - Livre électronique des RFTP 2024

P8. REVITALIZING THE EOSINOPHILIC ASTHMA

PHENOTYPE : AN INNOVATIVE APPROACH USING THE
ELEN INDEX

CHAIMA BRIKI1, FATMA GUEZGUEZ1,2,SABAA BOUBAKRI1, BALSAM BARKOUS1,2,
WIEM BEN HMID1,NARJESS ABESS1, AMANI SAYHI1,2 ,INES GHANOUCHI1,2
,SONIA ROUATBI1,2

1 DEPARTMENT OF PHYSIOLOGY AND FUNCTIONAL EXPLORATIONS, UNIVERSITY HOSPITAL OF
FARHAT HACHED, SOUSSE, TUNISIA 2 RESEARCH LABORATORY HEART FAILURE, LR12SP09,
UNIVERSITY HOSPITAL OF FARHAT HACHED, SOUSSE, TUNISIA

INTRODUCTION

Asthma presents diverse phenotypes, with the eosinophilic pattern being of
particular concern. In this regard, the ELEN index which uses a peripheral blood-
based algorithm offers an innovative approach to predict eosinophilic phenotype
without requiring the constraining induced sputum.

OBJECTIVE:
To evaluate the utility of the ELEN index in assessing the severity of asthma.

METHODS

We conducted a cross-sectional study on 100 asthma-patients who consulted
over a period of six months. The study population was divided in two groups based
on the ELEN index (G1: 39 patients with eosinophilic pattern and G2: non-
eosinophilic pattern including 61 patients). Anthropometric and demographic
characteristics were recorded. Data related to asthma were completed for all
patients (asthma control, respiratory symptoms, asthma severity, number of
exacerbations and hospitalizations during the previous year). Spirometry with BD
test was performed for all individuals with measurement of pre and post
bronchodilator values of FEV1(%) ,FVC ( % ) and FEV1/FVC ratio. The GLI norms
were used.

RESULTS

The sample was female-dominated (70.6%), almost 80% were overweight or obese
patients. Mean age and BMI were 44.3±13.3 (years) and 29.5±6 (Kg/m2),
respectively. Both groups were comparable for sex, age, height and
socioeconomic level. However, G1 had lower BMI (27.9±5.6 Kg/m2 in G 1 vs.
30.9±6.0 Kg/m2 in G2, p=0.012). Lung function was significantly more impaired
among G1 with a lower baseline FEV1% (67±17 in G1 vs. 75±18 in G2). Obstructive
ventilator impairment was present in 51.3% in G1 vs. 34.4% in G2 (p= 0.095).
Compared to G2, G1 had more severe asthma exacerbations requiring
hospitalization in the previous year (20.5% in G1 vs. 6.6% in G2, p=0.036).

55 | Pa g e